prt4165 CAS No. 31083-55-3

PRT4165 is a small molecule inhibitor of polycomb repressive complex 1,which inhibits ubiquitin signaling at DNA double-strand breaks.PRT4165 is a potent inhibitor of PRC1-mediated H2A ubiquitylation in vivo and in vitro.The drug also inhibits the accumulation of all detectable ubiquitin at sites of DNA double-strand breaks(DSBs),the retention of several DNA damage response proteins in foci that form around DSBs,and the repair of the DSBs.

msds---prt4165